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    搜索结果包含 pharmacokinetics properties 的内容

    Jul 06,2023
    发现新型RAGE/SERT双重抑制剂,可用于治疗阿尔茨海默病和抑郁症。其中药代动力学研究是通过委托AG真人国际(中国)官方官网进行
    Alzheimer's disease (AD) is a progressive and devastating neurodegenerative disorder, characterized by the presence of β-amyloid (Aβ) peptide plaques, neurofibrillary tangles, and neuroinflammatio
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    发现新型RAGE/SERT双重抑制剂,可用于治疗阿尔茨海默病和抑郁症。其中药代动力学研究是通过委托AG真人国际(中国)官方官网进行
    Jul 06,2023
    药物发现中的挑战之一是识别高质量的先导化合物。此研究中PK结果表明L12可作为针对PDE5的先导化合物,进一步研究和开发。L12的PK分析通过AG真人国际(中国)官方官网进行
    Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organi
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    药物发现中的挑战之一是识别高质量的先导化合物。此研究中PK结果表明L12可作为针对PDE5的先导化合物,进一步研究和开发。L12的PK分析通过AG真人国际(中国)官方官网进行
    Jul 06,2023
    ANO1是一个潜在的镇痛靶点。DFBTA是一种有效的ANO1抑制剂,具有优异的药代动力学特性。体内PK测试通过AG真人国际(中国)官方官网进行
    Current pain management is largely limited to opioids and non-steroidal anti-inflammatory drugs. Developing new analgesic drugs remains important to address the unmet medical needs of chronic pain pat
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    ANO1是一个潜在的镇痛靶点。DFBTA是一种有效的ANO1抑制剂,具有优异的药代动力学特性。体内PK测试通过AG真人国际(中国)官方官网进行
    Jul 06,2023
    Y180是一种口服Mpro抑制剂,可有效对抗野生型SARS-CoV-2及其变种。Y180在小鼠、大鼠和狗中具有良好的PK特性
    Y180, an orally available Mpro inhibitor, is effective against wild-type SARS-CoV-2 and variants. Y180 displayed satisfying PK properties in mice, rats and dogs, with oral bioavailabilities of 92.9%,
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    Y180是一种口服Mpro抑制剂,可有效对抗野生型SARS-CoV-2及其变种。Y180在小鼠、大鼠和狗中具有良好的PK特性
    Jul 06,2023
    PTX-HSN是一种高效纳米系统,具有较高耐受剂量,可将PTX递送至卵巢癌并增强主动肿瘤靶向性。此研究中所有体内实验均通过AG真人国际(中国)官方官网进行
    Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor targeting. The in vivo #toxicity,
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    PTX-HSN是一种高效纳米系统,具有较高耐受剂量,可将PTX递送至卵巢癌并增强主动肿瘤靶向性。此研究中所有体内实验均通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    QF-036是一种高效的HIV-1抑制剂,具有良好的和药代动力学特性,PK研究通过AG真人国际(中国)官方官网进行
    The favourable viral inhibitory activity and pharmacokinetic properties provide critical support for QF-036 as a promising anti-HIV therapeutic candidate. The pharmacokinetic studies were performed by Medicilon.
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    QF-036是一种高效的HIV-1抑制剂,具有良好的和药代动力学特性,PK研究通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    TR-107是人类线粒体蛋白酶ClpP的有效激活剂,PK分析通过AG真人国际(中国)官方官网进行
    The pharmacokinetic properties of TR‐107 were compared with other known ClpP activators including ONC201 and ONC212. TR‐107 displayed excellent exposure and serum t1/2 after oral administration. Pharmacokinetic analysis were evalsuated for pharmacokinetic
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    TR-107是人类线粒体蛋白酶ClpP的有效激活剂,PK分析通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    SKLB-197是一种有效且高度选择性的ATR抑制剂,PK研究通过AG真人国际(中国)官方官网进行
    SKLB-197, exhibits good pharmacokinetic properties, could be a promising lead compound for drug discovery targeting ATR. The pharmacokinetic (PK) studies were performed by Medicilon.
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    SKLB-197是一种有效且高度选择性的ATR抑制剂,PK研究通过AG真人国际(中国)官方官网进行
    Jun 28,2023
    JND003是一种新型选择性ERRα激动剂,可缓解非酒精性脂肪肝和胰岛素抵抗,PK和组织分布测定通过AG真人国际(中国)官方官网进行
    JND003 is orally bioavailable and exhibits high grade of distribution in liver and abdominal adipose tissues. Pharmacokinetics (PK) and Tissue Distribution Assays of JND003 were performed at Medicilon.
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    JND003是一种新型选择性ERRα激动剂,可缓解非酒精性脂肪肝和胰岛素抵抗,PK和组织分布测定通过AG真人国际(中国)官方官网进行